Study indicates that the Omicron wave and the rollout of vaccines led to almost 100% seropositivity and boosted anti-spike IgG titers in children and adolescents medrxivpreprint UZH_en omicron vaccines seropositivity igG covid COVID19 SARSCoV2
By Bhavana KunkalikarMay 15 2023Reviewed by Lily Ramsey, LLM In a recent study posted to the medRxiv* preprint server, researchers discussed the presence of persistent humoral immunity among children and adolescents during the coronavirus disease 2019 pandemic.
Multiple serological studies were carried out to identify SARS-CoV-2 infections among children and adolescents and to assess the prevalence of antibodies at various stages of the pandemic. The study randomly selected classes and divided them into three strata based on school level: grades one to two for lower school, grades four to five for middle school, and grades seven to nine for upper school.
The seroprevalence rate exhibited a significant increase between T4 and T5, rising from 46.4% to 96.9% in the entire study population. Among unvaccinated children and adolescents, the rate increased from 31.3% to 95.8%. The vaccination rate for children and adolescents increased from 25.3% at T4 to 43.4% at T5.
Moreover, children and adolescents with previous seronegative samples who had a history of SARS-CoV-2 infection showed the smallest increase and lowest titers in T4 and T5.
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