One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells.
Rockefeller UniversityAug 28 2024 From beta blockers to antihistamines, these essential, life-saving medications trigger winding biochemical pathways, via these receptors, to ultimately prevent a heart attack , or stop an allergic reaction in its tracks.
Uncharted territory This family of receptors are known as GPCRs, or G protein-coupled receptors. Their accessory proteins are known as RAMPs, short for receptor activity-modifying proteins. RAMPs help transport GPCRs to the cell surface and can vastly alter how these receptors transmit signals by changing the receptor's shape or influencing its location.
But wading through every GPCR-RAMP interaction was a daunting task. With three known RAMPs and almost 800 GPCRs, searching through every possible combination was impractical, if not impossible. In 2017 Emily Lorenzen, then a graduate student in Sakmar's lab, began a collaboration with scientists at the Science for Life Laboratory in Sweden and Sweden's Human Protein Atlas Project to create an assay capable of screening for GPCR-RAMP interactions.
Antibodies Antihistamines Assay Drugs GPCR Heart Heart Attack Interactome Laboratory Protein Receptor Technology
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