The impact of depressive symptoms, use of antidepressants, and epigenetic age acceleration (EAA) on mortality in postmenopausal individuals.
By Tarun Sai LomteJun 13 2024Reviewed by Lily Ramsey, LLM In a recent study published in Aging , researchers evaluated the impact of depressive symptoms, use of antidepressants, and epigenetic age acceleration on mortality in postmenopausal individuals.
While antidepressants have potential health benefits, they are associated with various side effects. Postmenopausal individuals represent a high-risk group for depressive symptoms and antidepressant use. Their vulnerability to age-related conditions may increase with depressive symptoms or antidepressant use.
EDSs were repeatedly evaluated at enrolment and during a three-year follow-up to examine temporal changes. Antidepressant use was similarly examined for temporal changes. EAA was defined using four epigenetic clocks – Hannum, PhenoAge, GrimAge, and Horvath. Besides, the relationship between EAA and EDS, antidepressant use, or both was evaluated. Causal mediation analyses examined moderating or mediating effects of EAA on the association between EDSs/antidepressants and mortality risk.
The odds of EDSs or the combined exposure reduced with age, higher physical activity, education, and income but increased with body mass index and among current smokers. All-cause mortality risks increased with age and were reduced among Black and Hispanic subjects relative to While and non-Hispanic individuals, respectively.
Antidepressant Mortality Cardiovascular Disease Chronic Depression Diabetes Metabolic Syndrome Syndrome
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