A recent study in Science Advances found that early-life tobacco exposure, including in-utero and early smoking initiation, accelerates biological aging, emphasizing the importance of reducing exposure to improve health outcomes.
By Priyanjana Pramanik, MSc.May 6 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Science Advances, researchers investigated the impact of early-life tobacco exposure on aging-related diseases. They found that in-utero tobacco exposure is associated with increases in the rate of biological aging.
Recent reviews have underscored the importance of quantifying biological age through various biomarkers to predict health outcomes accurately. Early-life environmental exposures, particularly tobacco exposure, have been identified as significant risk factors for adverse health outcomes in adulthood.
The study utilized data from the UK Biobank, a population-based cohort study comprising approximately half a million participants aged 37 to 73 years enrolled between 2006 and 2010. After exclusions, a total of 276,259 participants were included. Sensitivity analyses were conducted to assess robustness, including adjustments for additional confounders and stratified analyses by demographic and lifestyle factors.
Furthermore, a clear dose-response trend emerged regarding the smoking initiation age, with earlier commencements correlating with a more pronounced acceleration in biological aging markers.
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