Emory researcher David Weiss has spent years studying a baffling phenomenon called heteroresistance, in which a tiny fraction of bacteria remain resistant to antibiotics, while the remainder succumb.
Emory Health SciencesAug 2 2024 Recently, he brought his scientific acumen to the equally deadly threat of fungal bloodstream infections in patients receiving bone marrow transplants. Bloodstream infections can be lethal in these patients, including infections from Candida parapsilosis, a species of fungi that can live in the digestive tract and occasionally make it into the bloodstream.
In a new paper in Nature Medicine, the team described how they worked with collaborators around the world to gather 219 strains of C. parapsilosis from patients at Sloan Kettering and locations in France, Germany and China. The study found that heteroresistance was the reason a small number of patients developed bloodstream infections, despite receiving prophylaxis with the antifungal drug micafungin.
David Weiss, professor at Emory University's School of Medicine and director of the Emory Antibiotic Resistance Center "There are thousands of mutations," says Liao. "I asked my algorithm to choose at most 10. One of the advantages of machine learning is that you don't need to sequence the whole genome, just find a few spots that are informative enough that they can predict."
Bone Marrow Transplant Antibiotic Antibiotic Resistance Antifungal Bacteria Cancer Candida Fungi Machine Learning Medicine Penicillin Prophylaxis Research
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Researchers discover source of deadly fungal infections in bone marrow transplant patientsEmory researcher David Weiss has spent years studying a baffling phenomenon called heteroresistance, in which a tiny fraction of bacteria remain resistant to antibiotics, while the remainder succumb.
Read more »
Study explores machine learning for classifying functional neurological disorderIn a study published in the Journal of Neurology, Neurosurgery & Psychiatry, David L.
Read more »
Inside Surrenne, The Emory’s Medi-Spa Five Storeys Below KnightsbridgeIf the pursuit of longevity in the most luxurious of surroundings is high on the agenda, then Surrenne is the place for you. Read Vogue’s spa review of Surrenne, here.
Read more »
Study links social and non-social synchrony to romantic attractivenessRomantic relationships and attraction among humans have been the focus of numerous psychological and neuroscientific studies. While these studies have unveiled some of the neural and mental processes associated with romantic bonding, many questions about their underlying mechanisms remain unanswered.
Read more »
Study links OCD improvement to brain activity shiftA recent study from Baylor College of Medicine and Texas Children's Hospital has identified a specific neural activity pattern as a novel biomarker to accurately predict and monitor the clinical status of individuals with obsessive-compulsive disorder (OCD) who have undergone deep brain stimulation (DBS), a rapidly emerging therapeutic approach...
Read more »
Study links improved dietary fat quality to reduced cardiovascular and diabetes riskThe impact of dietary fat quality on lipid metabolites and its association with reduced cardiometabolic disease risk.
Read more »