A retrospective cross-sectional study of 106 women with Hashimoto's thyroiditis found that thyroid function markers (TgAb, fT3, TSH) are associated with chronotype and daytime sleepiness. Most women had an intermediate chronotype and normal daytime sleepiness. Evening chronotype was associated with higher fT3 levels, and increased daytime sleepiness was linked to higher TgAb and TSH.
Xia & He Publishing Inc.May 29 2026 Background and objectives Hashimoto's thyroiditis , an autoimmune disease with a prevalence 2–7 times higher in women than in men, is associated with daytime sleepiness .
The present study aimed to test the hypothesis that thyroid function is associated with chronotype and daytime sleepiness in women with HT. Methods This retrospective cross-sectional study included women with confirmed HT. Demographic, clinical and laboratory data were collected. The reduced Morningness-Eveningness Questionnaire and the Epworth Sleepiness Scale were used to assess chronotype and daytime sleepiness, respectively.
Based on rMEQ, women were categorized as having a morning , intermediate or evening chronotype. Based on ESS, women were categorized as having normal or increased daytime sleepiness. Results Overall, 106 women, aged 43 ± 12 years, were included. Most had normal daytime sleepiness , and the majority had an intermediate chronotype , while only one had a morning chronotype .
Age was significantly associated with chronotype . There was a significant association between chronotype and thyroglobulin antibodies . Free triiodothyronine levels were significantly higher in women with an evening chronotype than in those with an intermediate chronotype . Daytime sleepiness was significantly associated with TgAb and thyroid-stimulating hormone .
TgAb levels were significantly higher in women with increased daytime sleepiness than in those with normal daytime sleepiness. Conclusions Approximately one-third of women have an evening chronotype, and approximately one-third had increased daytime sleepiness. TgAb, fT3, and TSH are associated with daytime sleepiness or chronotype in women with HT. Further investigation is required for the underlying mechanisms.
Source:Xia & He Publishing Inc. Journal reference:Biloglav, Z., et al. . Chronotype and Daytime Sleepiness in Women with Hashimoto’s Thyroiditis: A Cross-sectional Pilot Study. Exploratory Research and Hypothesis in Medicine. DOI: 10.14218/erhm.2025.00071. https://www.xiahepublishing.com/2472-0712/ERHM-2025-00071
Hashimoto's Thyroiditis Chronotype Daytime Sleepiness Thyroid Function Women
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