A study on HIV-1 neutralizers, individuals with HIV-1 who naturally develop potent and broad neutralizing antibodies, reveals important information about the dynamics and durability of antibody responses. The findings can inform the design of future HIV-1 vaccine regimens.
Human immunodeficiency virus type 1 ( HIV-1 )- neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery . But as no nAb-eliciting vaccines are yet available, only data from HIV-1 neutralizers—persons with HIV-1 who naturally develop broad and potent nAbs—can inform about the dynamics and durability of nAb responses in humans, knowledge which is crucial for the design of future HIV-1 vaccine regimens.
To address this, we assessed HIV-1-neutralizing immunoglobulin G (IgG) from 2,354 persons with HIV-1 on or off antiretroviral therapy (ART). Infection with non-clade B viruses, CD4, being off ART and a longer time off ART were independent predictors of a more potent and broad neutralization. In longitudinal analyses, we found nAb half-lives of 9.3 and 16.9 years in individuals with no- or low-level viremia, respectively, and 4.0 years in persons who newly initiated AR
HIV-1 Neutralizing Antibodies Vaccine Discovery Antibody Responses HIV-1 Neutralizers
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