Researchers at Karolinska Institutet in Sweden have developed a new comprehensive mapping of genetic activity for understanding the causes of chronic pain.
Karolinska InstitutetOct 4 2024 The study, published in Nature Communications, opens way to more efficient non-addictive treatment for chronic pain and potentially headache disorders.
The scientists behind the new study have developed an innovative atlas of the somatosensory system during neuropathic pain called iPain, focusing on the dorsal root ganglia and trigeminal ganglia. We found that this lasting pain state is associated with gene sets in nociceptors typically found in senescent cells, suggesting that senescence, commonly associated with aging, plays a novel role in chronic nervous system disorders, even in young individuals." Their discovery was validated through studies on animal models and human patients with chronic pain, including those suffering from diabetic neuropathy.
Chronic Pain Pain Genetic Headache Nerve Neuropathic Pain Opioids Research
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