In posttraumatic stress disorder (PTSD), intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person's quality of life.
Apr 18 2024Broad Institute of MIT and Harvard In posttraumatic stress disorder , intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person's quality of life. About 6 percent of people who experience trauma develop the disorder, but scientists don't yet understand the neurobiology underlying PTSD.
Caroline Nievergelt, co-first and corresponding author on the study and professor in the Department of Psychiatry at the University of California, San DiegoThe findings both confirm previously discovered genetic underpinnings of PTSD and provide many novel targets for future investigation that could lead to new prevention and treatment strategies.
But these analyses pointed to different genetic loci across datasets, and many studies struggled to distinguish loci that were specific to PTSD risk from those that were also linked to conditions such as depression and cardiovascular disease. Genetic datasets have also historically focused on people of European ancestry, even though there is a disproportionately high burden of trauma and PTSD among people of African, Native American, and Latin American ancestry in the United States and globally.
Although previous studies found a higher prevalence of PTSD in females than males, the researchers did not find evidence for this in their data. They examined the X chromosome, which earlier studies did not do, and found five loci linked with PTSD. But they add that these changes on the X chromosome would have similar effects in males and females.
Brain Chromosome Depression Genes Genetic Genetics Genomics Neurons Post-Traumatic Stress Disorder Psychiatry Research Stress Trauma X Chromosome
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