Study reveals altered neural signature in patients with depression

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Study reveals altered neural signature in patients with depression
AnhedoniaBiomarkerBrain
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As parents, teachers and pet owners can attest, rewards play a huge role in shaping behaviors in humans and animals.

Texas Children 's Hospital Jul 15 2024 Rewards – whether as edible treats, gifts, words of appreciation or praise, fame or monetary benefits – act as positive reinforcement for the associated behavior.

Anhedonia is a cardinal symptom of depression and other psychiatric conditions Human beings derive pleasure through various physical or mental activities, sensory experiences and interactions with family and friends.

As their brain activity was being monitored, these patients performed a perceptual discrimination task called the probabilistic reward task , a well-validated behavioral task that objectively measures anhedonia by observing subtle changes in behavior related to reward. Our study has addressed a longstanding fundamental question in neuroscience – which specific brain region and signal regulates the classic reward bias response, a famous example of which is the Pavlovian conditioning where dogs learned to associate the sound of a ringing bell to food." Reward bias response is altered in patients with treatment-resistant depression Next, Sheth and his team conducted the PRT in four individuals with severe treatment-resistant depression.

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