A randomized clinical trial (RCT) to investigate the effectiveness of curcumin in lowering depression among obese individuals with diabetes mellitus type 2 (T2DM).
By Pooja Toshniwal PahariaReviewed by Lily Ramsey, LLMJul 30 2024 In a recent study published in Nutrients , researchers performed a randomized clinical trial to investigate the effectiveness of curcumin in lowering depression among obese individuals with diabetes mellitus type 2 .
T2DM and depression coexist in a bidirectional manner, with those afflicted facing disability-related job loss, noncompliance with medical treatment, and increased mortality risks. The study excluded individuals with type 1 diabetes, metabolic syndrome, glucose tolerance impairment, maturity-onset diabetes of the young , dyslipidemia, gestational diabetes, severe hypertension, and those taking insulin injections or antidiabetic medicines apart from metformin.
The researchers assessed depression, the primary study outcome, using the Patient Health Questionnaire-9 . They withdrew participant blood to measure biomarkers at baseline and three months, six months, nine months, and one year.The researchers performed enzyme-linked immunosorbent assays to evaluate serum serotonin levels and Homeostatic Model Assessment of Insulin Resistance to assess insulin resistance.
RANSEL, RANSOD, and TAS were enhanced among curcumin consumers, whereas the placebo group showed higher MDA .
Curcumin Diabetes Type 2 Diabetes Anti-Inflammatory Antioxidant Anxiety Biomarker Blood Cardiometabolic Cell Chronic Clinical Trial Creatinine Depression Depressive Disorder Diabetes Mellitus Diet Disability Exercise Fasting Glucose Hba1c Insulin Insulin Resistance Major Depressive Disorder Mortality Nutrients Oxidative Stress Placebo Public Health Serotonin Stress Turmeric
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