Scientists have found consistent positive genetic correlations of coffee intake with substance use and obesity in US and UK adults of European ancestry.
By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Danielle Ellis, B.Sc.Jun 20 2024 The study is published in the journal Neuropsychopharmacology .
Excessive coffee intake, in contrast, has been found to increase the risks of other substance use and misuse, abnormal lipid profile, pregnancy loss, gastrointestinal complications, and cardiovascular impairment. Furthermore, they have compared their findings with the largest available genome-wide association studies of coffee intake from the UK Biobank. They have used these datasets to explore cohort-specific associations with coffee intake across two different populations.
The gene-based analysis identified 165 candidate genes, including four previously identified coffee intake-related genes and six novel candidate genes. Such discrepancies in findings could be attributed to the differences in coffee intake amount between studies, as higher coffee intake is likely to reduce its genetic associations with BMI and obesity. The scientists believe that future subgroup analyses may help explain contradictory associations between the genetics and prevalence of coffee intake with obesity-related traits.
As mentioned by the scientists, cultural variation in coffee intake habits between the US and the UK could be attributed to the observed inconsistencies in genetic relationships. Moreover, comparatively higher levels of coffee intake or caffeine intake from high-caloric beverages have been documented in the US. This might explain the observed negative impact of coffee intake on health outcomes in the US cohort.
Genetic Obesity Caffeine Cardiovascular Disease Cognitive Function Compound Diabetes Gene Genes Genome Liver Liver Disease Neurodegenerative Diseases Neuropsychopharmacology Phenotype Pregnancy Type 2 Diabetes
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