Study found that influenza vaccination is highly effective in preventing infection and hospitalization in children, though efficacy against certain subtypes like H3N2 remains limited due to small sample sizes.
By Dr. Sanchari Sinha Dutta, Ph.D.Oct 6 2024 New research shows that flu vaccines provide strong protection for children but underscores the need for improved efficacy against specific subtypes like H3N2 .
In Spain, children under five and older adults aged 65 years or above have the highest rates of influenza-related hospitalization. Regarding virus transmission, evidence indicates that children play a key role in the community circulation of the virus and in the amplification of influenza epidemics. This test-negative case-control study analyzed SiVIRA data from 12 regions and 27 hospitals in Spain. Children who tested positive for the influenza virus were regarded as cases, and test-negative children were regarded as controls.
Effectiveness of Influenza Vaccination The effectiveness of influenza vaccination was estimated by virus type, subtype, or clade. Potential confounding factors, including sex, age, epidemiological week, presence of chronic conditions, and region or hospital for acute or severe respiratory infections, were adjusted in the analysis.
The effectiveness of influenza vaccination was estimated to be 77% against any influenza infection among hospitalized children with severe acute respiratory infections. In this analysis, the low efficacy against H3N2 remained, further emphasizing the challenges in drawing firm conclusions for this subtype due to the small sample size.
Flu Efficacy H1N1 H3N2 Hospital Influenza Mutation Primary Care Research Respiratory Severe Acute Respiratory Vaccine Virus
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