Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division.
Reviewed by Megan Craig, M.Sc.Sep 28 2023 It is very common in solid tumors and it is linked to the aggressive spread of cancer, that is to say, metastasis. Given that metastasis causes 90% of cancer-related deaths, it is vital to unravel the details of this process.
"We have long considered caspases as agents that induce cell death in response to DNA damage. However, our findings indicate that they may also play a pro-invasive role by promoting DNA damage. This research broadens our understanding of cancer biology and paves the way to exploring new therapeutic approaches to tackle metastasis," explains Dr. Milan.
The laboratory led by Dr. Milan at IRB Barcelona has been studying the role of chromosomal instability in cancer and metastasis for many years. In previous studies, published in 2021 and 2018, the team explored the effects of aneuploidy on this process. In the present work, they describe the third axis of action, namely the influence of DNA damage on the invasiveness of cancer cells.
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