Nerve cells in the brain receive thousands of synaptic signals via their 'antenna', the so-called dendritic branch.
University Hospital of Bonn Sep 2 2024 Nerve cells in the brain receive thousands of synaptic signals via their "antenna", the so-called dendritic branch. Permanent changes in synaptic strength correlate with changes in the size of dendritic spines. However, it was previously unclear how the neurons implement these changes in strength across several synapses that are close to each other and active at the same time.
A recent study suggests a new perspective on how neighboring synapses coordinate their response to plasticity signals. Researchers from Bonn and Japan have found that the sharing of proteins and calcium makes synaptic plasticity a collective action in which the behavior of one synapse influences how the others can respond.
Strong competition among neighboring spines The researchers from Bonn and Japan used the release of glutamate, an important excitatory neurotransmitter in the brain, in conjunction with computer-assisted models to investigate the molecular processes of the plasticity of several spines. Spines, mushroom-shaped protrusions of nerve cells, are found in the brain and can strengthen synaptic connections.
Hospital Nerve Neurons Research Synapse Technology
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