Study reveals immune characteristics of long-COVID Coronavirus COVID19 LongCOVID Rheumatology PASC ragoninstitute BrighamWomens MassGeneralNews MIT medrxivpreprint
By Pooja Toshniwal PahariaOct 2 2022Reviewed by Benedette Cuffari, M.Sc. Coronavirus disease 2019 symptoms may persist beyond the acute phase of severe acute respiratory syndrome coronavirus 2 infection, typically about 28 days following the initial diagnosis. Post-acute sequelae of coronavirus disease 2019 , often referred to as ‘long COVID,’ is often used to describe the presence of these long-term symptoms following the initial recovery from COVID-19.
About the study In the present study, researchers explored humoral immune response alterations to SARS-CoV-2, common CoVs, herpesviruses, and several vaccine antigens to investigate whether pathogen-targeted Abs could provide information relevant to the pathogenesis of long COVID. Moreover, they focused on a single long COVID endotype, wherein they applied systems serology to rheumatic disease patients who developed mild to moderate SARS-CoV-2 infection, 50% of whom developed long COVID.
Ab-dependent neutrophil phagocytosis and seropositive assays were also performed. To study the enrichment of a particular inflammatory-driven long COVID endotype, humoral responses of COVID-19-recovered patients with SARD were assessed. Study findings Related StoriesIn the analysis, 17 long COVID and SARD patients and 26 non-long COVID patients were profiled, 95% vaccinated against COVID-19. Moreover, 79% of the study participants were women.
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