Announcing a new article publication for Zoonoses journal. Zoonotic transmission of severe acute respiratory coronavirus 2 (SARS-CoV-2) has been found to result in infections in more than 30 mammalian species.
Compuscript LtdNov 27 2024 Announcing a new article publication for Zoonoses journal. Zoonotic transmission of severe acute respiratory coronavirus 2 has been found to result in infections in more than 30 mammalian species. The SARS -CoV-2 spike protein binds to the host's angiotensin converting enzyme 2 cell surface receptor to gain entry into the cell.
This study investigated the conservation of 24 host protein targets, including the entry proteins ACE2 and transmembrane serine protease 2 ; 21 proteins in the interferon-I antiviral response pathway; and tethrin, a protein that suppresses new virion release from cells.
This pathway approach revealed that 1) 13 proteins were conserved, whereas five lacked data sufficient to determine specific critical amino acids; 2) variation in protein-protein interfaces is tolerated for many amino acid substitutions, and these substitutions follow taxonomic clades rather than correlating with empirically determined species infection status; and 3) four proteins contained potential domains or specific amino acids whose substitution may result in PPI disruption.
This work provides evidence that certain substitutions in four IFN-I antiviral pathway proteins appear able to disrupt interactions and may be distinctive to resistant species, thus potentially aiding in determining species' likelihood of transmitting SARS-CoV-2.Journal reference:Mayasich, S. A., et al. In Silico Analysis of Cross-Species Sequence Variability in Host Interferon Antiviral Pathway Proteins and SARS-CoV-2 Susceptibility. Zoonoses. doi.org/10.15212/ZOONOSES-2024-0028.
SARS SARS-Cov-2 ACE2 Amino Acid Angiotensin Cell Coronavirus Enzyme Protein Receptor Respiratory Severe Acute Respiratory Spike Protein
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