Dyslexia is a common learning difficulty in which genes often play a role.
Max Planck Institute for PsycholinguisticsDec 18 2024 How do genes associated with dyslexia relate to brain structure in the general population? In a large-scale study published in Science Advances, a team of scientists led by the Max Planck Institute for Psycholinguistics in Nijmegen found that genetic variants that increase the chance of dyslexia were associated with differences in brain areas involved in motor coordination, vision, and language.
Genetic chance of dyslexia To investigate how the genetic contribution to dyslexia is related to brain structure, Soheili-Nezhad and his team undertook a large-scale genetic study. The researchers used data from more than a million people collected by the company 23andMe, which revealed many genetic variants that increase the chance of a person having dyslexia.
Internal capsule A higher genetic chance of dyslexia was associated with lower volume in brain areas involved in movement coordination and processing of speech sounds. In contrast, dyslexia-related genetic variants were associated with increased volume in the visual cortex. Brain development "These results are consistent with dyslexia as a complex trait that can involve a combination of altered cognitive processes", explains Clyde Francks, senior author of the study. "Although our study used data from adults, some of the brain changes probably relate to altered development of the brain during early stages of life, for example in the foetus or during infancy, which then remain stable across the lifetime.
Dyslexia Children Gene Genes Genetic Language Research UK Biobank
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