Study reveals surprising link between biological age and child development ChildhoodAging BiologicalAge GrowthandDevelopment CognitiveHealth Adiposity Exposome Europe Schoolchildren eLife
By Dr. Liji Thomas, MDJun 7 2023 Apart from chronological age, the biological age in adults is associated with health and resilience in the face of disease. Children might also be at risk of health complications if their biological age exceeds their chronological age. A new research paper published in the journal Computational and Systems Biology, Epidemiology and Global Health explores how child development relates to two new candidate markers of biological age.
These are unified to derive biological clocks and global assessments of cellular aging. Accelerated aging, which is the difference between predicted and chronological age, is a marker of age-related diseases and mortality risk. This is in contrast with the significance of accelerated DNA methylation age in adults, which could reflect reduced biological capital, being the result of increased efforts to repair the wear and tear on the cells caused by external and intrinsic factors operating during daily life.
They used multiple biological clocks, including those based on telomere length, DNA methylation, and gene expression, as well as those derived from the levels of various proteins and metabolites. In particular, they tested the transcriptome- and immunometabolic-based age for consistency with other clocks.
Girls had longer telomeres than boys. This is well-known to be the case in adult life, but its presence in children indicates a biological foundation, which mediates increased risk when males are faced with other health risk factors. All the markers of biological age are linked to higher body mass index and fat mass. Conversely, every marker except for telomere length was linked with increased height.
This indicates the need for clocks that reflect clinical situations rather than merely the chronological age.
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