The accumulation of fats in the liver is driven by high-fat diets and obesity, and is becoming an increasingly prevalent global health concern.
Fujita Health UniversityOct 7 2024 Characterized by excessive fat accumulation in the liver, this condition poses significant risks for various metabolic disorders . While much of the existing research has focused on fat metabolism within the liver itself, emerging findings emphasize the critical role of the gut in this complex process. Proglucagon-derived peptides , including glucagon, GLP-1 , and GLP-2, are known to be the key hormones that regulate lipid metabolism in the liver.
"When we subjected both GCGKO mice and control mice to an HFD for one week, the GCGKO mice exhibited a significantly lower increase in hepatic free fatty acid and triglyceride levels, along with reduced adipose tissue weight," highlighted Dr. Seino. These effects were attributed to a decrease in lipid absorption via the CD36 pathway in the intestinal tract, despite a reduced fat-burning capacity in the liver.
Notably, the researchers found that despite lower fat-burning activity in the liver, the primary factor preventing fat accumulation was reduced fat absorption from the intestines. HFD-fed GCGKO mice also showed lower plasma triglyceride levels during the oral fat tolerance test , further confirming reduced lipid absorption.
Related StoriesAdding further, Dr. Seino notes, "If we can examine in more detail how PGDPs specifically regulate lipid absorption in the gut, we hope to clarify the relationship between diet, hormones, and intestinal bacteria sufficiently to recommend a diet that is less conducive to obesity and fatty liver disease."
Liver Liver Disease Bacteria Diabetes Diet Education Endocrinology Global Health GLP-1 Glucagon Metabolic Disorders Metabolism Nutrients Obesity Peptides Research Students Triglyceride
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study sheds light on mechanisms behind liver fibrosis and potential therapiesNew research from the University of Pittsburgh School of Pharmacy sheds light on the processes that lead to liver fibrosis and suggests a novel treatment approach for this common and serious condition.
Read more »
Baby chicks study sheds light on the brain's innate ability to recognize facesIs the brain of animals and humans naturally wired to recognize faces? Is there an innate biological mechanism that explains this ability? Questions like these have been fueling a debate that involves, on the opposite side, those who believe that face recognition is a skill that can be learned through experience and exposure to faces and those who...
Read more »
Cohort study sheds light on why the flu vaccine is less effective in older peopleSo-called high-dose flu vaccines are available for older people. The reason: their immune system does not always respond sufficiently well to the standard flu vaccines. Why this is the case and the molecular processes behind it are not yet understood.
Read more »
New Study Sheds Light on Chronic Fatigue Syndrome and Long COVID-19 FatigueA new study by Iñigo Murga at the University of the Basque Country (UPV/EHU) reveals that chronic fatigue syndrome (CFS) presents with diverse symptoms, requiring different diagnostic approaches. The research, published in Frontiers in Psychiatry, highlights the need for tailored treatment based on individual patient profiles.
Read more »
Study sheds new light on immune dysfunction in children with severe infections and inflammatory diseasesA new study led by King's College London, Imperial College London and the University of Edinburgh, has characterized the similarities and differences between immune cell profiles in children with different infections and inflammatory diseases.
Read more »
McGill study sheds light on delusion patterns in youth psychosisNew findings from McGill University researchers could help clinicians understand the course of delusions in youth and young adults that signal the need for a timely intervention to prevent a full relapse of psychosis.
Read more »