Study shows consistent efficacy of Paxlovid regardless of age, number of vaccinations, comorbidities Efficacy Coronavirus Disease COVID SARSCoV2 nirmatrelvir ritonavir Paxlovid Ontario medrxivpreprint PublicHealthON UofT MGHToronto MemorialU
In Ontario, Paxlovid has been widely available since April 2022. The therapeutic has received universal funding for all COVID-19 patients residing in community-based settings with authorization for use only in SARS-CoV-2-infected individuals with advanced age, comorbidities, and under-vaccinated.
Using a population-based observational cohort study, researchers evaluated Paxlovid's effectiveness in reducing hospitalizations and deaths from COVID-19, while Omicron and its subvariants are predominant. Paxlovid prescription data, SARS-CoV-2 testing data, and vaccination data were obtained from the ODB , C19INTGR, and COVAXON databases, respectively. Comorbidity data were obtained from the CIHI databases, OHIP database, and other validated disease-specific ICES cohorts. Data analysis was performed at ICES.
Hospitalizations or deaths in the 30 days were lower among Paxlovid-treated patients compared to the unexposed patients [two percent versus four percent, equating to 44% RR , wOR 0.6]. In addition, the relative chances of mortality significantly lowered among treated individuals .
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Northern, midlands and cockney accents are still looked down on, study showsA new study shows judgement around accents is still unfortunately rife, with northerners facing the brunt of it.
Read more »
Study shows likely SARS-CoV-2 transmission between different rooms of a quarantine hotelThe results of this study, published in the Emerging Infectious Diseases journal, underline the enhanced transmissibility of the Omicron variants of the virus, which takes advantage of small airstreams to jump to new hosts. 'Our findings emphasize the importance of ventilation and integrity of building structure in quarantine facilities.'
Read more »
Dementia prevalence is declining among older Americans, study findsThe prevalence of dementia in the U.S. is declining among people over age 65, dropping 3.7 percentage points from 2000 to 2016, according to a new RAND Corporation study.
Read more »
Viral whole genome study in the United States identifies ORF-disrupting mutations in monkeypox virusResearchers used whole genome sequencing to evaluate monkeypox virus samples from Washington and Ohio states in the United States and identified 25 samples with open reading frame (ORF)-disrupting mutations.
Read more »
Online abuse of female journalists a crisis - studyMore than 1,000 women were interviewed, the majority of them having suffered online violence.
Read more »