The interactions between rheumatoid arthritis (RA) and major depressive disorder (MDD).
By Dr. Sushama R. Chaphalkar, PhD.Nov 7 2023Reviewed by Lily Ramsey, LLM In a review published in Nature Reviews Rheumatology, researchers discussed the interactions between central and peripheral immunobiological mechanisms associated with rheumatoid arthritis and major depressive disorder .
Data suggest that depression is a risk factor for RA, and patients diagnosed with RA early in life are more susceptible to depression. Additionally, RA patients with depression are observed to show functional progression as well as a reduced response to treatment, leading to poor outcomes. However, the precise biological mechanisms underlying this association are not clearly understood.
Related StoriesThe activated sensory neurons then relay the signal back to the cerebral cortex of the brain via the spinal cord. The signal is then transmitted to higher brain centers, which modulates the immune system locally and systemically. For example, during inflammation, the recruitment of peripheral monocytes to the brain is associated with dendrite remodeling and cognitive impairment, potentially leading to depression. Chronic peripheral inflammation in RA induces local microglial activation within the brain, leading to altered microglial expression.
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