A Ludwig Cancer Research study has for the first time exhaustively analyzed immune cells known as neutrophils that reside in brain tumors, including gliomas, which develop in the brain itself, and cancers that spread there from the lung, breast and skin.
, especially in the most aggressive types of gliomas and BrMs, raising questions about their potential role in tumor progression.
Maas, Joyce and colleagues report that tumor-associated neutrophils tend to cluster around the malformed and leaky blood vessels in tumors and switch off gene expression programs that inducewhile turning on genes that support cell survival—thus lengthening their lifespans. These findings were confirmed in pioneering studies performed in mouse models of brain cancer.
But TANs, it turns out, aren't just victims of immunosuppression. They're also its perpetrators. The researchers show that TANs clustered around tumor blood vessels associate with and apparently suppress cytotoxic T cells—the frontline forces of the immune system that kill cancer cells and are engaged by most approved immunotherapies.
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