Chronic stress raises blood pressure. New research from Juntendo University, Japan, reveals that voluntary exercise prevents hypertension (high blood pressure) by restoring STAT3 levels in the amygdala.
Juntendo UniversityFeb 20 2025 Chronic stress raises blood pressure . New research from Juntendo University, Japan, reveals that voluntary exercise prevents hypertension by restoring STAT3 levels in the amygdala. Using a rat model, the study found that stress lowered Stat3 expression, leading to increased blood pressure , while exercise reversed this effect.
The amygdala is a key player in the body's cardiovascular response. When exposed to prolonged stress, this region triggers an increase in blood pressure, heightening the risk of heart disease. To understand how exercise influences this process, researchers subjected rats to three weeks of chronic stress, with one group engaging in voluntary wheel running.
"The improvement of cardiovascular dynamics after exercise is attributed to the rescue of Stat3 expression possibly because of mechanisms such as neuroprotection and anti-inflammation," explains Prof. Waki while elaborating on the underlying mechanism.
Blood Pressure Brain Exercise High Blood Pressure Amygdala Chronic Gene Gene Expression Heart Physical Activity Research Stress Transcription
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