Researchers identified and tested study characteristics that may bias estimates of all-cause mortality risk associated with low-volume alcohol consumption using theory and evidence.
By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Jul 29 2024 In a recent study published in the Journal of Studies on Alcohol and Drugs , a group of researchers identified and tested study characteristics that may bias estimates of all-cause mortality risk associated with low-volume alcohol consumption using theory and evidence.
About the study The present study analyzed 107 cohort studies to explore the relationship between alcohol consumption and all-cause mortality risk, identified in a systematic review and meta-analysis. Further meta-analyses were conducted on subgroups categorized as "lower" or "higher" quality based on potential biases in reference groups classified as abstainers. Focus was placed on individuals with low-volume alcohol consumption, defined as one to two drinks per day .
Significant heterogeneity was managed through mixed regression analysis weighted by inverse variance. Statistical analyses used SAS Version 9.4, with results converted to exponential scales and significance tests assuming two-tailed p-values or a 95% confidence interval.
Adjusted RR estimates for low-volume drinkers showed significantly lower all-cause mortality risk in the entire pooled set of 107 studies and models meeting combinations of lower study quality criteria .
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