Study suggests Vitamin D prescription lowers hip fracture incidence SciReports vitaminD VD hip fracture hipfracture
By Pooja Toshniwal PahariaAug 14 2023Reviewed by Sophia Coveney In a recent study published in Scientific Reports, researchers examined the relationship between vitamin D supplementation and osteoporosis-related fracture incidence using osteoporotic population information retrieved from the National Database of Health Insurance Claims and Specific Health Checkups of Japan.
Vitamin supplementation has been shown to lower vertebral and nonvertebral fracture risks, enhance bone mass, and improve calcium regulation. However, data on the effects of active metabolites of the vitamin on preventing hip fractures are limited. In addition, individuals who developed osteoporosis-associated fractures at study initiation or within three months were excluded. Individuals were enrolled between September 2012 and March 2016.
A subgroup analysis was performed by stratifying participants based on the type of vitamin D prescribed, including alfacalcidol , calcitriol , and eldecalcitol individually or in combination . At follow-up, a total of 26,845 untreated individuals developed fractures, including 4,008 hip, 20,197 vertebral, and 2,640 radial fractures. The numbers of corresponding fractures among treated individuals were 687, 6,730 and 981, respectively. Fracture incidence was significantly lower among PS-matched treated individuals compared to controls [6.3% versus 5.7% , HR, 0.9].
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