Alcohol exposure leads to accumulation of oxidatively damaged proteins in neuronal cells. Differentiated cells are more susceptible to alcohol-induced oxidative protein damage despite higher resistance to cytotoxicity.
By Dr. Sanchari Sinha Dutta, Ph.D.May 9 2024Reviewed by Benedette Cuffari, M.Sc. A recent study published in the journal Antioxidants reports that alcohol exposure can lead to the accumulation of oxidatively damaged proteins in neuronal cells.
In 2016, the estimated global mortality due to harmful alcohol use exceeded three million individuals. Considering disability-adjusted life years, alcohol use has been associated with over 5% of the global burden of disease. Previous epidemiological studies have identified an association between alcohol consumption and over 200 somatic diseases.
Alcohol-induced neurotoxicity was measured through a wide range of assays, including cell viability quantification, mitochondrial morphology and functionality assessments, production of reactive oxygen species , and cellular accumulation of oxidatively damaged proteins. Post-mortem brain tissues obtained from alcohol-addicted individuals were also analyzed to determine the reproducibility of any in vitro observations in humans.
The microscopic observations indicated that alcohol exposure is associated with a significant reduction in neurite projections. Accumulation of oxidatively damaged proteins Total protein carbonyl content was assessed as a measure of oxidatively damaged proteins. To this end, alcohol exposure significantly increased the accumulation of oxidatively damaged proteins in both differentiated and undifferentiated cells after 12 or 24 hours of exposure. However, this accumulation was significantly higher in differentiated cells after 12 hours of exposure to 50 mM ethanol.
Protein Brain Cell Dementia Diabetes Diabetes Mellitus Disability Ethanol Heart Heart Disease Ischemic Heart Disease Morphology Mortality Neuroblastoma Oxidative Stress Stress
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Stress activates brain regions linked to alcohol use disorder differently for women than men, finds studyWhen exposed to stress, people with alcohol use disorder engage parts of the brain associated with both stress and addiction, which may cause them to drink or crave alcohol after a stressful experience, suggest the authors of a study published in Alcohol: Clinical and Experimental Research.
Read more »
Study Finds Link Between Intestinal Microorganisms and Excessive Alcohol ProductionA professor at Amsterdam UMC has received a grant to study the causes of excessive alcohol production in the intestines of overweight individuals. The study aims to find ways to prevent related diseases such as diabetes and cardiovascular disease.
Read more »
Study reveals decrease in alcohol use among young adults during COVID-19The effects of the coronavirus disease 2019 (COVID-19) on young individuals' alcohol usage and difficulties.
Read more »
Parents' watchful eye may keep young teens from trying alcohol, drugs: StudyTeenagers are less likely to drink, smoke or use drugs when their parents keep tabs on their activities—but not necessarily because kids are more likely to be punished for substance use, suggests a new study in the Journal of Studies on Alcohol and Drugs.
Read more »
Study finds obstacles to alcohol, drug treatment higher for rural AmericansRural Americans are less likely to initiate care for substance use disorders and to receive ongoing care compared with those who live in urban areas, according to a new study.
Read more »
Australian study finds large support for blocking online alcohol contentIn a new study published in Health Promotion Journal of Australia, La Trobe University researchers found large support for a browser plug-in that blocks online alcohol-related imagery to prevent young people being influenced to start drinking alcohol or drinking to excess.
Read more »