In a report published in Nature Cell Biology, researchers at Baylor College of Medicine, Texas Children's Hospital, the University of Manitoba and collaborating institutions revealed an unexpected way in which the protein OTX2 drives the progression of medulloblastoma – the most common aggressive childhood brain cancer.
Baylor College of Medicine Jul 18 2024 In a report published in Nature Cell Biology, researchers at Baylor College of Medicine , Texas Children 's Hospital , the University of Manitoba and collaborating institutions revealed an unexpected way in which the protein OTX2 drives the progression of medulloblastoma – the most common aggressive childhood brain cancer . The findings suggest that targeting OTX2 or its effects can have therapeutic relevance.
Splicing factors are involved in alternative splicing, a cellular process that allows cells to produce different proteins from the instructions encoded in a single gene. "Imagine that three cooks meet in the kitchen to bake a cake," Werbowetski-Ogilvie said. "They all begin with the same instructions, but each cook adds a different twist to the cake.
Dr. Tamra Werbowetski-Ogilvie, professor of pediatrics, hematology-oncology at Baylor, Texas Children's and adjunct professor at the University of Manitoba
Brain Brain Cancer Cancer Cell Cell Biology Children Gene Genes Hematology Hospital Medicine Oncology Pediatrics Protein Research Splicing Stem Cells Transcription
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