A group of researchers led by Xavier Saelens and Sven Eyckerman at the VIB-UGent Center for Medical Biotechnology discovered how a protein linked to the human immune system wards off HIV-1 and herpes simplex virus-1 by assembling structures in the cell that lure in these viruses and then trap them or even take them apart.
Vlaams Instituut voor BiotechnologieOct 9 2024 The research was spearheaded by first author George Moschonas, published in Cell Host and Microbe, and could be used to devise new strategies to combat these viruses.
To date, researchers were unsure how the antiviral properties of the MX protein worked. However, in this new study led by Xavier Saelens and Sven Eyckerman of the VIB-UGent Center for Medical Biotechnology and in collaboration with Beate Sodeik , Zeger Debyser , Linos Vanderkerckhove and Nico Callewaert , the secret of the MX protein's antiviral activity was uncovered.
In an illuminating discovery, the researchers show how the MX protein drives the assembly of virus decoy structures that mimic nuclear pore complexes.
HIV Biotechnology Cell Cell Nucleus Genetic Herpes Simplex Herpes Simplex Virus HIV-1 Immune System Protein Research Virus
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