The role of Cutibacterium acnes in improving the skin's barrier function.
By Dr. Priyom Bose, Ph.D.Aug 23 2023Reviewed by Lily Ramsey, LLM A recent study published in the Science Advances Journal evaluated the role of Cutibacterium acnes in improving the skin's barrier function with regard to antimicrobial activity, transepidermal water loss, and paracellular diffusion.
The skin also harbors many beneficial microbes which protect the host from pathogenic invasion. For these complex functions, keratinocytes synthesize lipids in the skin, accumulating in the stratum corneum, the outermost layer of the epidermis. Cutibacterium acnes is one of the most common commensal bacterial species on the skin barrier. This bacterium is associated with the development of acne vulgaris, a common skin disorder.
About the study The current study hypothesized that skin commensal bacteria influence lipid synthesis by keratinocytes, an essential component of the skin barrier. TAGs, minor components of lamellar bodies found in the stratum corneum, are most abundantly induced by C. acnes. However, the precise role of TAGs in epidermal homeostasis is poorly understood.
These findings indicate the possibility of linoleic acid being hydrolyzed from TAG, which subsequently contributes to acylceramide synthesis to aid in skin barrier function.
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