A novel diagnostic model using machine learning (ML).
By Dr. Liji Thomas, MDApr 24 2024Reviewed by Lily Ramsey, LLM With millions of cases of bladder cancer around the world, the need for tools to ensure a timely diagnosis of this condition is a matter of concern. Scientists recently used mitochondrial-related genes , known to be involved in the progression of the disease, to build a novel diagnostic model using machine learning .
Although bladder cancer is more prevalent in developed populations, its prognosis remains relatively poor despite medical advancements. This has driven the development of better diagnostic tools, prognostic models, and therapeutic approaches. Additionally, mitochondrial abnormalities can cause oxidative stress on cellular components such as DNA and proteins, increasing cancer risk, conferring resistance to cancer therapies, and promoting tumor growth.
What did the study show? The researchers analyzed 165 bladder cancer samples and 67 controls to study the differential expression of mitochondrial-related genes . They identified 752 differentially expressed MRGs, with 440 showing increased expression and the rest downregulated. These findings were consistent across two additional datasets, demonstrating that this model more effectively differentiates BC from control samples than single gene biomarkers.
Bladder Cancer Cancer Diagnostic Genes Cell Cell Metabolism Chemicals Gene Machine Learning Metabolism Mitochondria Oxidative Stress Protein Smoking Stress Transcription Tumor
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study reveals novel approach to promote efficient uptake of ASOs into cancer cellsAntisense oligonucleotides (ASOs) are next-generation drugs that can treat disease by blocking the transfer of harmful messages from our genes.
Read more »
New study to test novel psychedelic compound as potential treatment for alcohol use disorderModern mental health company Clerkenwell Health announced today that it is working with clinical-stage biotechnology company Beckley Psytech on a Phase IIa study investigating whether a novel psychedelic compound, combined with psychological support, could be an effective treatment for alcohol use disorder (AUD).
Read more »
Novel combination therapy shows promise in difficult-to-treat endometrial cancer, study findsIn a small, investigator-initiated phase 2 study by Dana-Farber Cancer Institute investigators, a novel combination of an antibody-drug conjugate and an immune checkpoint inhibitor showed notable activity in pre-treated patients with a difficult-to-treat form of endometrial cancer.
Read more »
Study shows one injection of novel drug cuts systolic blood pressure by up to 12 mmHgA single subcutaneous injection of the investigational drug zilebesiran, when added to existing treatment with a standard antihypertensive medication, reduced systolic blood pressure by between 4 to 12 mmHg on average at three months in patients whose blood pressure had remained uncontrolled despite compliance with their medication regimen,...
Read more »
Novel study compares fracture patterning in fatal, survived intimate partner violence casesIntimate partner violence (IPV) is an underreported global human rights issue that affects approximately 25% of women and 10% of men and is the leading cause of homicides among women worldwide. Multiple interventional studies have been conducted to screen for IPV.
Read more »
Novel study quantifies immense economic costs of mental illness in the USMental illness costs the U.S. economy $282 billion annually, which is equivalent to the average economic recession, according to a new study co-authored by Yale economist Aleh Tsyvinski.
Read more »