Actor Richard E Grant, comedian Matt Lucas and Shaun Of The Dead star Nick Frost are among those who will present their books at the festival.
Elsewhere, Love Actually screenwriter and director Richard Curtis will sit down with Scarlett Curtis for The Sunday Times culture interview, whilst Can You Ever Forgive Me? actor Richard E Grant will be in discussion with Emma Freud about his memoir A Pocketful Of Happiness.Meanwhile, comedian, writer and actor Matt Lucas will discuss his new book, with Little Britain sketch partner, David Walliams, set to give a performative reading.
Also discussing their palate, comedian Ed Gamble will join Great British Menu host Andi Oliver to share stories about life through the lens of food. History books will also get a look in, with Would I Lie To You? panellist David Mitchell, set to present Unruly: A History Of England’s Kings And Queens, which is his own account of England’s earliest monarchs.Other speakers at the event will explore faith and spirituality, with comedian Ruby Wax in discussion about how to navigate tough experiences with Buddhist monk Gelong Thubten.
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Identification of indications for albumin administration in septic patients with liver cirrhosisBackground Albumin infusion is the primary therapeutic strategy for septic patients with liver cirrhosis. Although recent studies have investigated the efficacy of albumin in the resuscitation stage of septic patients with liver cirrhosis, it remains unclear whether daily albumin administration can improve outcomes. Furthermore, the indications for initiating albumin therapy are not well defined. Methods Septic patients with liver cirrhosis were obtained from the Medical Information Mart for Intensive Care (MIMIC-IV 2.0) database. Marginal structural Cox models were employed to investigate the association between daily albumin infusion and 28-day mortality. We also aimed to explore under what circumstances enrolled patients could benefit most from albumin administration, based on the clinical parameters collected on the day of albumin infusion, including serum albumin concentration, serum lactate concentration, mean arterial pressure (MAP), and vasopressor dosage. Results A total of 2265 patients were included in the final analysis, of whom 1093 (48.3%) had received albumin treatment at least once. The overall 28-day mortality was 29.6%. After marginal structural modeling, daily albumin infusion was associated with a reduced risk of 28-day death (hazard ratio, 0.76; 95% CI 0.61–0.94). We found that patients benefit most from albumin infusion when initiated on the day of serum albumin concentration between 2.5 and 3.0 g/dL, serum lactate concentration greater than or equal to 2 mmol/L, MAP less than 60 mmHg, or vasopressor dosage between 0.2 and 0.3 mcg/kg/min (norepinephrine equivalent, NEE). Conclusions Albumin infusion is associated with a reduction in mortality in septic patients with liver cirrhosis under specific circumstances. Serum albumin concentration, serum lactate, MAP, and vasopressor dosage were found to be modifiers of treatment effectiveness and should be considered when deciding to initial albumin infusion.
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