Sudden cardiac death risk can be determined by genetic score Genetic SuddenCardiacDeath CardiacArrest Cardiology Polygenic riskscore CedarsSinai UAlberta broadinstitute BrighamWomens UW MassGeneralNews
By Nidhi Saha, BDSOct 3 2022Reviewed by Aimee Molineux Thus, this assessment score may help guide indications of implantable cardioverter-defibrillator in this group of patients.
More than 70% of sudden deaths caused by cardiac causes are unexpected and occur in patients without a significant risk of sudden death. Recognition of early signs of cardiac arrest like chest pain, back pain, inability to breathe, dizziness, fatigue, and seeking emergency help – support of defibrillator, cardiopulmonary resuscitation, and advanced life support, can save lives.
Here, the 5,488 study participants were genotyped. A raw GPSCAD score was determined for each participant – by multiplying the genotyping dosage for each risk factor by its weight and then summing the results of all variables of the scoring system. Ancestry-adjusted scores were derived using a linear regression model using a reference distribution from 1,000 genomes.
When adjusted for age and sex, the participants in the top GPSCAD decile had a 1.76-fold increased risk for SAD. Whereas controlling for left ventricular ejection fraction , familial history of SAD, and ECG score showed identical results.
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