Suddeninfantdeathsyndrome may have biologic cause
While rare, it is the leading post-neonatal infant death in the United States today, occurring in 103 out of 100,000a year. Despite the initial success of national public health campaigns promoting safe sleep environments and healthier sleep positions in infants in the 1990s in the United States, rates of cases have remained the same over the last three decades.
Researchers here collected tissue from the San Diego Medical Examiner's Office related to infant deaths between 2004 and 2011. They then examined the brain stems of 70 infants who died during the period and tested them for consistent abnormalities.2A/C receptor is altered in sudden infant death cases compared to control cases of infant deaths.
"The work presented builds upon previous work by our laboratory and others showing abnormalities in the serotonergic system of some SIDS infants," says the paper's lead author, Robin Haynes. "Although we have identified abnormalities in the serotonin 2A/C receptor in SIDS, the relationship between the abnormalities and cause of"Much work remains in determining the consequence of abnormalities in this receptor in the context of a larger network of serotonin and non-serotonin receptors that protect vital functions in cardiac and respiratory control when challenged. Currently, we have no means to identify infants with biological abnormalities in the serotonergic system.
Robin Haynes et al, Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome : part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits,
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