Glialcells eating synapses may enhance learning and memory tohoku_univ NatureNeuro
Nature Neuroscience
thanks Won-Suk Chung, Cagla Eroglu and the other, anonymous, reviewer for their contribution to the peer review of this work.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations., Representative images of pHRed expression and PV-IHC in PV-tTA; tetO-pHRed mice . Most PCs expressed pHRed. We have done 1 independent experiment ., PV-tTA mouse was crossed with tetO-FRET-sensor mouse.
Representative images of microglial engulfment of pHRed in the cerebellar white matter of the PV-pHRed mouse. pHRed is expressed in Purkinje cell axons. Condensed pHRed signals are highlighted by dashed circles. These pHRed signals are contained in the microglial process and soma. We have done 1 independent experiments ., Purkinje cell specific promoter-tTA mediated pHRed expression. AAV2/9 L7-4-tTA was injected in the lobule IV/V of the tetO-pHRed mouse.
=20.59, p < 0.0001; *** p = 0.0005 for WT vs inj.; ***p = 0.0002 for uninj. vs inj.). Data are shown as mean ± s.e.m.
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