Synthetic mucin gels against HIV-1 and HSV-2 transmission Mucin MucinGels HIV1 HSV2
By Bhavana KunkalikarSep 21 2022Reviewed by Aimee Molineux In a recent study published in the Advanced Science journal, researchers assessed the effectiveness of synthetic mucin gels in the inhibition of human immunodeficiency virus-1 and herpes simplex virus-2 transmission.
The team effectively incorporated either aldehydes or hydrazides into BSM molecules. When added to a solution, the resulting BSM aldehydes and hydrazides can create dynamic covalent hydrazone linkages, culminating in the creation of BSM gels. For the production of BSM derivatives, dimethylamino-morpholino-carbenium hexafluorophosphate coupling chemistry with N,N-diisopropylethylamine was employed.
Related StoriesBy using cross-linking chemistry of carbodihydrazide -hydrazone, BSM gels were produced. In comparison to BSM aldehyde and BSM hydrazide derivatives, BSM gels revealed two additional peaks at 798 cm-1 and 1260 cm-1. Additionally, for BSM gels, two hydrazide-specific peaks at 3226 cm-1 and 3317 cm-1 vanished. The data indicated hydrazide consumption along with hydrazone bond formation. Once a sufficient amount of stress was exerted, the bonds ruptured before regenerating.
Dynamic covalent or non-covalent bonding could create self-healing gels. Gels with delayed dynamic equilibrium are more stable due to the use of dynamic covalent bonds. The quick self-healing behavior of the gel, however, revealed rapid dynamic equilibrium in the dynamic covalent bonds of CDH-hydrazone-producing BSM gels.
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