A Case Report in BMCPediatr discusses a case of systemic Aspergillosis in a 19-month-old infant girl with interferon-gamma receptor one deficiency. The authors suggest considering this immunodeficiency while treating patients with systemic Aspergillosis.
Conclusion
systemic fungal infections such as Aspergillosis can occur in patients with interferon-gamma receptor one deficiency. This type of immunodeficiency should be considered in treating patients with systemic Aspergillosis.Bustamante J, Boisson-Dupuis S, Abel L, Casanova JL. Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity. Semin Immunol. 2014 Dec;26:454–70.
Dorman SE, Uzel G, Roesler J, Bradley JS, Bastian J, Billman G, King S, Filie A, Schermerhorn J, Holland SM. Viral infections in interferon-gamma receptor deficiency. J Pediatr. 1999 Nov;135:640–3.Roesler J, Kofink B, Wendisch J, Heyden S, Paul D, Friedrich W, Casanova JL, Leupold W, Gahr M, Rösen-Wolff A. Listeria monocytogenes and recurrent mycobacterial infections in a child with complete interferon-gamma-receptor deficiency: mutational analysis and evaluation of therapeutic options.
Lamhamedi S, Jouanguy E, Altare F, Roesler J, Casanova JL. Interferon-gamma receptor deficiency: relationship between genotype, environment, and phenotype . Int J Mol Med. 1998 Feb;1:415-8. doi:Auld B, Urquhart D, Walsh M, Nourse C, Harris MA. Blurring the lines in interferon {gamma} receptor deficiency: an infant with near-fatal airway disease. Pediatrics. 2011 May;127:e1352-5. doi:Zhang SY, Boisson-Dupuis S, Chapgier A, Yang K, Bustamante J, Puel A, Picard C, Abel L, Jouanguy E, Casanova JL.
Prucha M, Grombirikova H, Zdrahal P, Bloomfield M, Parackova Z, Freiberger T. Mendelian susceptibility to Mycobacterial Disease: the First Case of a diagnosed adult patient in the Czech Republic. Case Rep Immunol 2020 Dec 19;2020:8836685. doi:
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