The loss of lean mass has become a hot topic with new anti-obesity drugs, but such changes can occur with most successful weight loss interventions — without meaningful countermeasures.
DENVER — In addition to the established gastrointestinal side effects common with the highly effective anti-obesity drugs, there is growing discussion around their potential to contribute to the loss of lean mass, necessary to keep the metabolic engine running full-steam.
"It's what we would expect to see if you successfully lost weight with bariatric surgery or with an intense lifestyle intervention," said Fitch, who is the past president of the Obesity Medicine Association. "Excess adiposity is what makes us sick — not our weight," Fitch underscored."The amount of fat that people are losing is far more beneficial than maybe the potential that they've lost a little bit of lean mass," she said.
Nevertheless, patients can be reassured that the losses can be reversed with some effort, Fitch noted. A key condition to watch for in these patients is sarcopenia. Definitions of sarcopenia vary, but it is distinguished by low skeletal muscle mass and either low muscle strength — measured, for instance, with hand grip — or low muscle performance, such as reduced walking speed or muscle power, Fitch said.
Obesity Obese Bariatric Surgery Obesity Surgery Weight Loss Surgery Weight Loss Muscles Skeletal Myoblasts Skeletal Muscle Exercise Physical Activity Muscular Atrophy Muscular Atrophies Sarcopenia Skeleton Surgery Patient Safety Cancer Risk
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