Hydrogels are polymeric materials with three-dimensional network structures containing large amounts of water. They serve as sustained-release drug delivery systems as they can encapsulate various bioactive substances, including drugs, antigens, and even cells.
Tokyo University of ScienceFeb 13 2025 Hydrogel s are better drug delivery alternatives than conventional systems, as they are more biocompatible, biodegradable, and easily administered as an injectable scaffold.
To address this, a Takumi-shaped DNA unit was formed with only two ODNs. However, studies investigating its optimization as a sustained-release drug carrier or its retention ability are limited. Each ODN in the Takumi-shaped DNA structure was constructed with an eight-18 nucleotide-long palindromic stem attached to two cohesive parts on either side with a thymidine spacer. The ODNs form a self-dimer via the palindromic sequence, and each ODN was named according to the number of nucleotides in the stem and cohesive parts. For instance, 14s-2 refers to an ODN with a stem length of 14 nucleotides and a cohesive part of 10 nucleotides located at both ends of the stem.
The researchers also assessed the storage modulus of hydrogels, which helps understand how the hydrogel changes under different physical conditions, by varying lengths of cohesive parts, demonstrating that 10-nucleotide-long GC-rich cohesive parts exhibit better thermal stability and storage modulus compared to other formations.
Bases Doxorubicin Drug Delivery Drugs Hydrogel In Vivo Ligase Nanostructures Nucleic Acid Nucleotide Nucleotides Research Technology
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