For patients with 'good-risk' ductal carcinoma in situ (DCIS) who underwent breast- conserving surgery and did not receive radiotherapy, tamoxifen significantly decreased the risk of recurrence in the same breast, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.
American Association for Cancer ResearchDec 12 2024 For patients with "good-risk" ductal carcinoma in situ who underwent breast- conserving surgery and did not receive radiotherapy, tamoxifen significantly decreased the risk of recurrence in the same breast, according to results presented at the San Antonio Breast Cancer Symposium , held December 10-13, 2024.
The more information we can provide patients about the impact of specific treatments, the more we can empower patients to make choices that are right for them. I believe that being able to provide clear information to our patients leads to the best care." Wright and colleagues, including NRG/RTOG 9804 principal investigator Beryl McCormick, MD, a radiation oncologist at Memorial Sloan Kettering Cancer Center, sought to assess the efficacy of tamoxifen in preventing disease recurrence in patients from both trials who did not receive adjuvant radiotherapy. They analyzed results from 878 patients, 43% of whom received adjuvant tamoxifen. After a median follow-up of almost 15 years, 117 cases of ipsilateral recurrence were diagnosed.
Similarly, because the grade of the primary DCIS was significantly associated with the risk of an invasive ipsilateral recurrence, they adjusted for DCIS grade and found that tamoxifen was independently associated with reduced invasive recurrence. When adjusted for DCIS grade, patients who received tamoxifen were 51% less likely to experience an invasive ipsilateral recurrence than patients who did not receive tamoxifen.
Adjuvant Therapy Breast Cancer Cancer Carcinoma Ductal Carcinoma Hormone Oncology Radiotherapy Receptor Surgery
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