Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments.
University of Missouri-ColumbiaJun 27 2024 Research ers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments.
The researchers used losartan, a common medicine for treating high blood pressure, to inhibit the AGTR1 receptor in mice. This disrupted cancer growth, slowing the development of leukemia and led to longer survival. The next step is to further investigate losartan's effectiveness in treating human leukemia patients.
"When we treated mice with the AGTR1 inhibitor losartan, we observed that this commercially available drug shows great promise in reducing AML development while protecting against chemotherapy-induced cardiotoxicity," Kang said. "This finding shows great potential to both enhance the success of chemotherapy while protecting the heart."
Blood Pressure Chemotherapy Heart Leukemia Acute Myeloid Leukemia Cancer Cardiovascular Disease Cell Gene Gene Therapy Hematology Losartan Medicine Myeloid Leukemia Oncology Pharmaceuticals Receptor Reproduction Research Students Therapeutics
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