Researchers have identified specific brain lesions associated with reduced PTSD symptoms in veterans, providing a potential noninvasive neuromodulation target. TMS applied to this PTSD circuit could offer new hope for effective treatment.
By Dr. Priyom Bose, Ph.D.Reviewed by Benedette Cuffari, M.Sc.Sep 26 2024 Researchers pinpoint brain lesions that reduce PTSD symptoms in veterans, showing that targeting the PTSD circuit with TMS could lead to a breakthrough in noninvasive treatments for trauma survivors.
Neuromodulation is a powerful technique that activates or inhibits brain circuits associated with a given symptom or disorder. Preliminary assessments have shown that focal modulation of the amygdala with deep brain stimulation , responsive neurostimulation, and laser ablation are effective for managing PTSD.
About the study Based on a previous causal lesion-derived circuit model of PTSD, the current study identified TMS targets associated with PTSD symptoms independent of depression. All relevant data were obtained from the Vietnam Head Injury Study . The resting-state functional connectivity between each lesion location and all other brain voxels was estimated using a normative human connectome database. This approach created a whole brain “connectivity map” for each participant.
Amygdala Brain Stimulation Cortex Deep Brain Stimulation Depression Head Injury Neuroimaging Neuromodulation Neuroscience Post-Traumatic Stress Disorder Psychotherapy Stress Transcranial Magnetic Stimulation Trauma
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