The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers.
May 24 2024 Emerging data now show that inhibition of a specific metabolic pathway in infected cells can diminish latent infection and therefore the risk of downstream disease, as reported by researchers from the University of Basel and the University Hospital Basel in the journal Science.
Most people are carriers of EBV: 90% of the adult population are infected with the virus, usually experiencing no symptoms and no resulting illness. Around 50% become infected before the age of five, but many people don't catch it until adolescence. Acute infection with the virus can cause glandular fever -; also known as "kissing disease" -; and can put infected individuals out of action for several months.
EBV hijacks the metabolism of infected cells Researchers led by Professor Christoph Hess have deciphered how the immune cells infected with EBV -;the so-called B cells -; are reprogrammed. Known as "transformation," this process is necessary for the infection to become chronic and cause subsequent diseases such as cancer. Specifically, the team discovered that the virus triggers the infected cell to ramp up the production of an enzyme known as IDO1.
In the paper, which has now been published, the researchers were able to show that EBV upregulates the enzyme IDO1 already months before post-transplant lymphoma is diagnosed. This finding may help to develop biomarkers for the disease.
Virus Blood Blood Cancer Cancer Cell Drugs Enzyme Hospital Lymphoma Metabolism Pathogen Transplant Tumor
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