This new article publication from Acta Pharmaceutica Sinica B, discusses a transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption.
Compuscript LtdSep 26 2024
The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments. In this article, a transferrin receptor targeted immunostimulant is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting β-catenin signal pathway. To synthesize PTI, the photosensitizer conjugated TfR targeting peptide moiety -HAIYPRH) is unitized to encapsulate the transcription interrupter of ICG-001.
This research may inspire the development of antibody antibody-free strategy to activate systemic immune response in consideration of immunosuppressive conditions.Journal reference:Yan, B., et al. Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption. Acta Pharmaceutica Sinica B. doi.org/10.1016/j.apsb.2024.05.030.
Immunotherapy Receptor Antibody CCL4 Cell Cell Death Chemokine Ligand PD-L1 Phenotype Photodynamic Therapy Signal Pathway Transcription Tumor
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