A flavonoid-rich diet, including apples, tea, and dark chocolate, significantly lowers the risk of non-alcoholic fatty liver disease (NAFLD) and improves liver health biomarkers. These findings highlight the potential of dietary flavonoids in combating liver fat accumulation and inflammation.
By Tarun Sai LomteReviewed by Susha Cheriyedath, M.Sc.Dec 9 2024 Discover how a diet packed with flavonoid-rich foods like tea and apples could revolutionize liver health and cut your risk of fatty liver disease.
NAFLD is the accumulation of lipids in the liver without excessive alcohol intake or other causes. It can progress to inflammatory non-alcoholic steatohepatitis, cirrhosis, and fibrosis, leading to the loss of viable hepatic tissue and, eventually, liver failure. Its global prevalence has increased by over 50% in the past three decades.
In the present study, researchers assessed associations of flavonoid-rich diet with NAFLD incidence and imaging biomarkers of steatosis and liver fat in the United Kingdom Biobank cohort. More than 500,000 individuals aged 40–69 years were recruited from 2006 to 2010 in England, Wales, and Scotland. Baseline assessments were performed; additional data were obtained during 2009-12 through Oxford WebQ 24-hour dietary assessments.
Findings Unique Metabolism of Flavonoids: Flavonoids are poorly absorbed by the human body, with less than 5% absorption, and are rapidly metabolized into smaller fragments, many of which have unknown properties but contribute to their health effects. Based on flavonoid subclasses, the highest quartile of theaflavin and thearubigin, proanthocyanidin, flavan-3-ol, and flavonol was associated with a lower NAFLD risk than the lowest quartile. Participants in the highest FDS quartile had a significantly lower percentage of liver fat than the lowest quartile participants. Consistently, individuals with high intakes of apples and tea had a lower liver fat content than those with low intakes.
Liver Tea Alcohol Cardiometabolic Cardiovascular Disease Cirrhosis Diet Fatty Liver Fibrosis Flavonoid Imaging Lipids Liver Disease Metabolism Nutrition Research Steatosis Weight Loss
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