Both radiation and temozolomide, a generic chemotherapy treatment in pill form, have meaningful single-modality anti-tumor activity against slow-growing, low-grade gliomas.
ECOG-ACRIN Cancer Research GroupNov 25 2024 The randomized phase 3 trial E3F05 by the ECOG-ACRIN Cancer Research Group tested whether combined therapy using temozolomide alongside radiation therapy is more effective than radiation therapy alone in these patients. The trial followed 172 patients for more than 10 years, and its results have an immediate clinical impact by providing the first evidence from a randomized phase 3 trial that temozolomide improves long-term survival for these patients.
Dr. Schiff presented the striking results as a late-breaking abstract at the Society of Neuro-Oncology's 2024 SNO Annual Meeting. The trial was funded by the US National Institutes of Health's National Cancer Institute through its National Clinical Trials Network . "Because the RTOG 9802 trial was positive for a benefit from PCV chemotherapy, it was no longer ethical to have a radiation-alone arm in E3F05, which is why our trial was closed to accrual. Even though we could not enroll the entire group as planned, after following all patients on the trial, results reached statistical significance showing the benefit of combined-modality temozolomide versus radiation alone," said Dr. Schiff.
Radiation Therapy Temozolomide Cancer Gliomas Medicine Neurology Neuro-Oncology Oncology Research Surgery Tumor Vincristine
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