Ten-minute scan enables detection and cure of the most common cause of highbloodpressure QMUL NatureMedicine
The scan uses a short-acting dose of metomidate, a radioactive dye that sticks only to the aldosterone-producing nodule. The scan was as accurate as the old catheter test, but quick, painless and technically successful in every patient. Until now, the catheter test was unable to predict which patients would be completely cured of hypertension by surgical removal of the gland.
Professor Morris Brown, co-senior author of the study and Professor of Endocrine hypertension at Queen Mary University of London, said,"These aldosterone-producing nodules are very small and easily overlooked on a regular CT scan. When they glow for a few minutes after our injection, they are revealed as the obvious cause of hypertension, which can often then be cured. Until now, 99% are never diagnosed because of the difficulty and unavailability of tests.
Professor William Drake, co-senior author of the study and Professor of Clinical Endocrinology at Queen Mary University of London, said,"This study was the result of years of hard work and collaboration between centers. across the UK. Much of the 'on the ground' energy and drive came from the talented research fellows who, in addition to doing this innovative work, gave selflessly of their time and energy during the national pandemic emergency.
In most people with hypertension , the cause is unknown, and the condition requires life-long treatment by drugs. Previous research by the group at Queen Mary University discovered that in 5% to 10% of people with hypertension, the cause is a gene mutation in the adrenal glands, which results in excessive production of the steroid hormone aldosterone. Aldosterone causes salt to be retained in the body, driving up the blood pressure.
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