A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center.
Johns Hopkins Medicine Oct 25 2024
We identified the life cycle of tertiary lymphoid structures in patients with liver cancer, and the takeaway is that these structures may be very important in the generation of anti-tumor immunity and may increase the likelihood of curing the cancer." Yarchoan and his colleagues previously conducted the first clinical trials of immunotherapy before surgery for hepatocellular carcinoma.
Related StoriesWhen the investigators looked at biopsies taken before and after immunotherapy, they found that patients who developed these structures had what looked like precursors of tertiary lymphoid structures prior to beginning therapy. When the study's lead author, Daniel Shu, M.D., then a medical oncology fellow at Johns Hopkins, examined sites where the patients' tumors had been eliminated, he discovered a transformation in the tertiary lymphoid structures remaining at the site.
Lymph Node Carcinoma Hepatocellular Carcinoma Immunity Immunology Immunotherapy Liver Liver Cancer Medicine OCT Oncology Pharmaceuticals Research Surgery Therapeutics Tumor
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