The adaptive immunity of human endemic viruses biorxivpreprint immunity immunology virology human endemic virus viruses endemicvirus
By Dr. Chinta SidharthanMay 24 2023Reviewed by Lily Ramsey, LLM In a recent study posted to the bioRxiv* preprint server, researchers analyzed the viral genomes of 28 endemic viruses to study the evolution of the ability of viruses to evade the neutralizing antibodies elicited by vaccines or previous infections.
The early stages of pandemics are often characterized by high adaptive evolutionary rates, as was seen during the coronavirus disease 2019 pandemic and outbreaks related to various other respiratory viruses. Related StoriesViruses with potentially high antigenic evolution rates were identified based on the high evolutionary rates for the genes coding for receptor-binding proteins since the receptor-binding region is involved in antibody neutralization and harbors most mutations that allow antigenic escape.
The researchers only investigated endemic viruses since they were interested in understanding the antigenic evolution that occurs during the endemic phase and not the initial adaptive phase.
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