The WHO has reported more than 1,000 probable cases in 35 countries. Some children have required liver transplants; at least 22 have died. Researchers have been scrambling to find the cause
-2 was ruled out as a culprit. One of the infections seems to be from human adenovirus, a common bug in children that causes stomach upsets but does not make them very ill. A cluster of the strange hepatitis cases appeared shortly after a spike in adenovirus infections, though it was unclear what role the virus might be playing, because it is often present in healthy children too.
In the latest research, led by teams at the University of Glasgow and University College London, researchers investigated the blood and livers of 26 children with the strange hepatitis and compared the results with those from more than 100 children of the same age, including healthy children, children with adenovirus but normal liver function, and children with hepatitis for which the cause was known.
Collectively, the two studies found that 25 out of the 26 children with the mysterious hepatitis were also infected with adeno-associated virus 2 . This virus was rarely found in the children without that form of hepatitis and, when present in them, it was in much lower quantities.2 is a parvovirus that cannot replicate on its own but needs assistance from a “helper” virus such as an adenovirus or a herpesvirus. It is not known for causing illness but it is very contagious.
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